A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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Employing solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our investigate passions incorporate:
Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular kinds with recombination functionality.
Multicolor imaging of your bacterial nucleoid and mobile division proteins with blue, orange, and around-infrared fluorescent proteins
Regrettably, for years soon after Iijima’s report, the production of cleanse nanotubes was cumbersome. In 1996, nonetheless, the team of Richard Smalley at Rice University managed to create one-walled carbon nanotubes at large generate. Shortly right after, I contacted Smalley, and we made a decision to join forces to evaluate the transportation through a solitary carbon nanotube.
We acquire position-of-care diagnostics exam of neglected tropical health conditions within just resource-confined options, according to Crspr/Cas9 detecting of pathogen’s DNA in body fluids.
Cornelis (Cees) Dekker (Haren, seven april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en achieved 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
All parameters had been precisely the same for every panel During this online video, except for the initial placement from the 6hb rod (proven in blue) about the nanopore. Simulations that terminated early resulting from translocation of the rod with the pore are marked by a grey track record.
Instance (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim with the pore is highlighted in red, and also a 3D rendering in the movement from the DNA rod is exhibited.
2003, shown the very first biosensors manufactured away from a carbon nanotube; resolved the framework and mechanism of DNA repair service proteins; and discovery of a whole new method for fabricating good-point out nanopores for DNA translocation
1). The present–voltage curves confirmed important modulations with gate voltage, even at room temperature, which was per band bending inside a ~0.six eV bandgap semiconducting nanotube. These information also confirmed that the conductance may be modulated by six orders of magnitude by shifting the gate voltage. The results of this do the job — a space-temperature transistor comprised of just one carbon nanotube molecule — were being printed in Character in May 1998.
Screening pseudotopological and nontopological models https://www.ceesdekker.net for SMC-driven DNA loop extrusion from roadblock-traversal experiments
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2008, initial observation of protein-coated DNA translocation via nanopores; resolved the origin of your electrophoretic pressure on DNA in nanopores; identified a substantial velocity increase of microtubules in electric powered fields; uncovered an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of noise in carbon nanotubes in liquid
2004, discovery of new physics in translocation of DNA by way of nanopores; initial experimental analyze of ions conduction in nanofluidic channels; very first electrochemistry with individual solitary-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; very first electrical docking of microtubules on kinesin-coated nanostructures; to start with biophysics characterization on the mechanical properties of double-stranded RNA; and 1st single-molecule examine of DNA translocation by a restriction-modification enzyme.